1. Index test failures – lesions not evaluable by smartphone application.

Study	Total number of lesions (melanomas) successfully assessed by the each 'app'		Unevaluable lesions (%)	Number (%) of unevaluable melanomas
Wolf 2013 188 lesions (60 melanomas)a	Application 1	182 (60)	6 (3%)	0 (0%)
	Application 2	185 (58)	3 (2%)	2 (3%)
	Application 3	170 (59)	12 (6%)	1 (2%)
	Application 4	159 (54)	29 (15%)	6 (10%)
Maier 2015 175 lesions (number of melanomas: not reported; between 26 and 40)b	SkinVision	144 (26)	31 (18%)	Not reported (≤ 14)

^a52% (202/390) of all images reviewed for inclusion in the study were excluded prior to analysis by the applications.
 ^b10% (20/195) of all images reviewed for inclusion in the study were excluded due to poor image quality or incomplete imaging. The original sample of 195 lesions included 60 melanomas. The number of melanomas excluded on the basis of image quality and the number analysed by the application but not included by the study authors (considered as test failures for the purposes of this review) were not separately reported.