Dehghani Firouzabadi 2016.
| Methods | Design: 3‐arm parallel RCT | |
| Participants |
Number: 159 Women's age: 20 to 40 years Inclusion criteria: women aged 20 to 40 years with a male factor or unexplained infertility and basal FSH < 12 who had undergone assisted reproduction Exclusion criteria: azoospermia; presence of uterine myoma; endometriosis; hydrosalpinges; previous IVF/ICSI trials (successful or unsuccessful); history of endocrine disease such as diabetes and thyroid dysfunction; previous history of hysteroscopic operation due to submucosal myoma; intrauterine synechia Ovarian controlled hyperstimulation: antagonist protocol Fertilisation: ICSI Stage of the embryo at transfer: cleavage Embryo processing: fresh Number of embryos transferred: 1 to 3 |
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| Interventions |
Experimental (n = 53): hCG 500 IU (40 µL) intrauterine injection 7 minutes before ET Experimental (n = 53): hCG 1000 IU (40 µL) intrauterine injection 7 minutes before ET Control (n = 53): nothing before ET |
|
| Outcomes | Clinical pregnancy, miscarriage | |
| Notes |
Location: Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Period: April 2012 to March 2013 Power calculation: not mentioned Funding: not mentioned Trial registration: IRCT2012091310328N3 Publication type: full text |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Liable women were randomly assigned to 2 test groups in the ratio of 1:1 or to a control group according to computer‐generated random numbers (n = 53). |
| Allocation concealment (selection bias) | Unclear risk | Allocation concealment not mentioned |
| Blinding of participants and personnel (performance bias) All outcomes | High risk | Not blinded |
| Blinding of outcome assessment (detection bias) All outcomes | Low risk | Not blinded, but unlikely to induce bias |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Data reported on all randomised participants |
| Selective reporting (reporting bias) | Unclear risk | No live birth data |
| Other bias | Low risk | Similar baseline characteristics between groups after randomisation |