Comparison 5. Safety: Vertebroplasty versus placebo (sham) or usual care.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 New clinical vertebral fractures	6	840	Risk Ratio (M‐H, Random, 95% CI)	1.29 [0.46, 3.62]
2 New radiographic vertebral fractures	8	804	Risk Ratio (M‐H, Random, 95% CI)	1.14 [0.71, 1.84]
3 Number of serious other adverse events	5	821	Risk Ratio (M‐H, Random, 95% CI)	0.61 [0.33, 1.10]