Comparison 6. High vs low ALA omega‐3 fats (tertiary outcomes).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Blood pressure, mmHg ‐ ALA	4		Mean Difference (IV, Random, 95% CI)	Subtotals only
1.1 Systolic BP ‐ ALA	4	1671	Mean Difference (IV, Random, 95% CI)	‐0.87 [‐4.48, 2.75]
1.2 Diastolic BP ‐ ALA	4	1671	Mean Difference (IV, Random, 95% CI)	‐1.42 [‐4.40, 1.57]
2 Serious adverse events ‐ ALA	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Any serious adverse events	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.2 Bleeding	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.3 GI hospitalisation	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.4 Pulmonary embolus or DVT	1	708	Risk Ratio (M‐H, Random, 95% CI)	0.32 [0.01, 7.80]
2.5 Thrombophleibitis	1	13406	Risk Ratio (M‐H, Random, 95% CI)	1.59 [0.72, 3.51]
2.6 Urolithiasis	1	13406	Risk Ratio (M‐H, Random, 95% CI)	0.80 [0.47, 1.36]
3 Side effects ‐ ALA	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Dropouts due to side effects	5	3480	Risk Ratio (M‐H, Random, 95% CI)	2.10 [0.66, 6.71]
3.2 Abdominal pain or discomfort	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3.3 Diarrhoea	1	708	Risk Ratio (M‐H, Random, 95% CI)	3.82 [0.82, 17.88]
3.4 Nausea	1	110	Risk Ratio (M‐H, Random, 95% CI)	6.29 [0.33, 118.93]
3.5 Any gastrointestinal side effect ‐ ALA	4	3450	Risk Ratio (M‐H, Random, 95% CI)	2.06 [0.62, 6.80]
3.6 Pain (joint, lumbar, muscle pain)	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3.7 All side effects combined	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4 Dropouts ‐ ALA	6	3663	Risk Ratio (M‐H, Random, 95% CI)	1.08 [0.92, 1.25]