DO HEALTH.

Trial name or title	Vitamin D3‐ omega3‐ home exercise‐ healthy ageing and longevity trial (DO‐HEALTH)
Methods	RCT
Participants	Community dwelling adults 70 years and older, 50% of seniors enrolled based on a fall in the year before enrolment
Interventions	Each for 3 years: Arm 1: omega‐3 (1 g/d, ratio EPA:DHA = 1:2) and vitamin D3 (2000 IU/d) capsules and strength home exercise (3 × 30 min/week) Arm 2: omega‐3 (1 g/d, ratio EPA:DHA = 1:2) and vitamin D3 (2000 IU/d) capsules and flexibility home exercise (3 × 30 min/week) Arm 3: omega‐3 (1 g/d, ratio EPA:DHA = 1:2) and placebo capsules and strength home exercise (3 × 30 min/week) Arm 4: omega‐3 (1 g/d, ratio EPA:DHA = 1:2) and placebo capsules and flexibility home exercise (3 × 30 min/week) Arm 5: placebo and vitamin D3 (2000 IU/d) capsules and strength home exercise (3 × 30 min/week) Arm 6: placebo and vitamin D3 (2000 IU/d) capsules and flexibility home exercise (3 × 30 min/week) Arm 7: placebo and placebo capsules and strength home exercise (3 × 30 min/week) Arm 8: placebo and placebo capsules and flexibility home exercise (3 × 30 min/week)
Outcomes	Primary: non‐vertebral fractures, functional decline, blood pressure, cognitive decline, rate of any infection Secondary: other fractures, falls, pain in knee osteoarthritis, musculoskeletal changes, gastro‐intestinal symptoms, mental and oral health, quality of life, life‐expectancy, cardiovascular events, cancer, glucose measures, cost‐benefit. All endpoints supported by a DO‐HEALTH biomarker study
Starting date	Registered on trials registry: 6 December 2012 Study start date: December 2012 Estimated study completion date: November 2017
Contact information	Heike Bischoff‐Ferrari (PI), Centre on Aging and Mobility, University of Zurich
Notes	NCT01745263 EudraCT: 2012−001249‐41 www.do‐health.eu