Shinto 2015.

Trial name or title	N‐3 PUFA for vascular cognitive aging
Methods	RCT
Participants	Older adults (80 years and older) at high risk for cognitive decline and dementia of Alzheimer's type
Interventions	Each for 3 years: Arm 1: omega‐3 fish oil (1.65 g/d EPA + DHA) Arm 2: soybean oil placebo (1.65 g/d)
Outcomes	Primary: total cerebral white matter volume Secondary: biomarkers of endothelial health, total brain atrophy, medial temporal lobe atrophy, ventricular expansion, trail making test part B, digit symbol WAIS‐R, cerebral blood flow, fractional anisotropy within frontal gyri
Starting date	Registered on trials registry: 24 September 2013 Study start date: May 2014 Estimated study completion date: March 2019
Contact information	Alena Borgatti, borgatti@ohsu.edu; James Dursch, dursch@ohsu.edu; Gene Bowman and Lynne Shinto (PIs), Oregon Health and Science University
Notes	NCT01953705