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. 2019 May 14;9:7368. doi: 10.1038/s41598-019-43075-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The temporal scaling of survival curves and aging trajectories. (a) The aging trajectories as a function of age rescaled by lifespan for the in-house collection of gene-expression data for four long-lived mutants and C. elegans wild-type (Bristol-N2, stock DRM), and three groups of N2 wild-type worms treated with life-prolonging RNAi or bacteria carrying only the empty feeding vector (FV) without an RNAi insert. The dashed line is a guide-to-eye. (b) The survival curves from (a) as a function of age rescaled by lifespan. In both panels, all markers are colored according to the lifespans of the strains (see Table 1 for the lifespans): red for small and green for large lifespans. Overall, the scaling spans almost tenfold variation in median adult lifespan, ranging from 17 to 160 days.