Table 3.
Transcription factors, RNA-binding proteins and miRNAs whose targets are significantly enriched in the list of potential transcriptomic biomarkers of age (327 genes).
| Transcription factors or RNA-binding proteins (WormExp)a | FDR |
|---|---|
| DAF-16 targets97 | 4.6e-7 |
| CEC-3 targets (spr-5 mutant, generation 10)98 | 2.0e-4 |
| small RNAs decreased by starvation at P099 | 1.3e-3 |
| PQM-1 L3 targets100 | 1.4e-3 |
| Rb/E2F pathway (DPL-1, EFL-1, LIN-35), intestine101 | 2.7e-3 |
| PMK-1 targets down in Day 15 vs. Day 638 | 3.8e-3 |
| age-regulated ELT-2 targets36 | 3.8e-3 |
| up by CSR-1 and w/out CSR-1-bound 22G RNA102 | 7.1e-3 |
| proteins interacting with CEY-1103 | 7.1e-3 |
| MUT-14, SMUT-1 (DEAD box)104 | 1.6e-2 |
| Hox gene targets (LIN-39, MAB-5, EGL-5)100 | 3.3e-2 |
| Transcription factorsa,b 32 | |
| NHR-1, NHR-10, NHR-8641 | |
| ELT-6 37 | |
| ZTF-9 105 | |
| MAB-3 | |
| miRNA (TargetScan) a,c | |
| miR-57 | |
| miR-244 | |
| miR-253 | |
| let - 7 /miR-48/84/241/795 42, 43 | |
| miR-245 | |
| miRNA (MirTarBase) a,d | |
| miR-59-3p | |
| miR-256 | |
| miR-1819-3p | |
| miR-60-3p 44 | |
| miR-52-5p | |
aLongevity-related regulators are highlighted in bold. bThe top six transcription-factor hits are reported. c,dThe top five miRNA hits from each of the databases.