Table 4.
A list of top-10 compounds predicted by CMAP to reverse the progression along the aging direction.
| Compounda | PubChemID | p valuea |
|---|---|---|
| anisomycin | 253602 | <0.0001 |
| camptothecin b | 24360 | <0.0001 |
| GW-8510 | 6539118 | <0.0001 |
| H-7 | 3542 | <0.0001 |
| lanatoside C | 3879 | <0.0001 |
| alsterpaullone | 5005498 | 0.0001 |
| doxorubicin | 31703 | 0.0002 |
| azacitidine | 9444 | 0.0003 |
| tonzonium bromide | 11102 | 0.0004 |
| metamizole sodium | 522325 | 0.0004 |
aCompound names and p values are taken from the CMAP database. bThe compounds initially chosen for lifespan testing are highlighted in bold. Camptothecin did not pass the initial test for a sparing effect on aggregation, thus it was not tested for lifespan effects.