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. 2019 May 14;9:7379. doi: 10.1038/s41598-019-43781-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Schematic of the bottom-up fabrication procedure for nanoholes array-based optical fiber probe. The entire procedure is divided into five sections: polishing optical fiber tip, PS nanosphere self-assembled on optical fiber tip, PS nanosphere etched by oxygen plasma, E-beam evaporating Au layer on optical fiber tip, PS nanosphere removed using organic solvent of tetrahydrofuran. Optical microscope images of fiber tip for each experiment section is shown in the top right corner. (b) A photograph of the optical fiber sensing probe. The enlarged inset is a SEM image of Au nanohole array. Scale bar, 1μm in the inset of (b).