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. 2019 May 14;9:7379. doi: 10.1038/s41598-019-43781-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Schematic drawing of alternating PAH/PSS bilayers absorbed on optical fiber tip by electrostatic interaction. (b) Wavelength shifts of resonant dip λ₁ with the increase of PAH/PSS bilayers. (c) The second order surface sensitivity curves for resonant dip λ₁. (d) Scheme depicting the side view of a flow channel for measuring Con A binding to RNase B immobilized on gold hole array. (e) Real-time resonant shift of dip λ₁ at different concentrations of Con A. (f) Resonant wavelength shifts in response to specific binding of Con A with RNase B on optical fiber sensing probe for various concentrations. The error bars present the standard deviations of three repeated measurements. The red curve is fitted using the Langmuir isotherm.