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. 2019 May 14;10:2060. doi: 10.1038/s41467-019-10004-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Hemostatic properties of the matrix gel in a pig cardiac puncture injury model. a Schematic diagram of the surgical procedure. b Gross view of the rapid hemostasis and sealing following cardiac puncture injury: the ventriculus sinister of the pig hearts was pierced by a 6 mm (inner diameter) needle, causing immediate high-pressure blood expulsion, subsequently continuing blood expulsion following needle removal. Then, the matrix gel was injected to cover the blood hole and rapidly irradiated with UV. After UV-induced rapid polymerization, the bleeding stopped completely within 10 s (four experimental operations were carried out). c Scanning electron micrographs of the interface between the pig heart puncture wound and the hydrogel. These sections derive from immediate postoperative autopsy on the heart of one pig, which was immediately killed after successful hemostatic treatment. Scale bar: 50 μm (left plates); 10 μm (right plates, enlarged). d Images of a heart autopsy following killing after two 2 weeks of postoperative recovery, the hydrogel still adhering to the wound, without any gap between gel and tissues, indicating continuous strong bonding at the healing interfaces. e Tissue staining images of the interface between pig heart cardiac tissue and the matrix gel, after 2 weeks of postoperative recovery. Scale bar: 200 μm (n = 4) Source data are available in the Source Data file