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. 2019 May 14;9:7372. doi: 10.1038/s41598-019-43758-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of HKlincR1 leads to reduced E2F8 levels and altered cell cycle in H460 (A) qRT-PCR analysis of HKlincR1 expression relative to β-actin following HKlincR1 knockdown in H460, H1755 and A549 using two independent siRNAs. Non-targeting (NT) siRNA was used as a control. (B) Cell viability measured by crystal violet assay following HKlincR1 knockdown using two different siRNAs vs siNT control, in H460, H1755 and A549. (C–E) Incucyte proliferation assays for H460, H1755 and A549 lung cancer cells. (F) Kaplan-Meier plot of overall survival in TCGA LUAD³⁸ cohort (N = 464) stratified by HKlincR1 expression levels, partitioned on the 75^th percentile. Blue: upper quartile. Orange: lower 3 quartiles. Kaplan-Meier plot was generated using survival⁶⁵ and survminer packages (based on ggplot2) in R.