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. 2019 May 8;10:494. doi: 10.3389/fneur.2019.00494

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Copyright © 2019 Zhuang, Liu, Shi, Liu and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Post-hoc analyses. Thresholds were set at a corrected p < 0.05, determined by Monte Carlo stimulation. (A) Compared with the control group, aMCI participants showed a significant decrease of ALFF in left inferior frontal gyrus, superior temporal gyrus and insula, while increased ALFF in right cuneus, calcarine and bilateral posterior cingulate and precuneus. (B) Further post-hoc tests of the significant interactions of diagnosis and genotype revealed that, aMCI C carriers showed decreased ALFF in the interactive brain regions compared with control C carriers. In addition, the ALFF value of C carriers was higher than that of TT genotype in control group. IFG inferior frontal gyrus, STG superior temporal gyrus, CAL calcarine, PreCUN precuneus. *Indicates a statistical difference between groups, P < 0.05.