Table 1.
Characteristics | No. of patients (%) |
||||
---|---|---|---|---|---|
All patients (N = 205) | 20 Gy EBRT (N = 63) | 30 Gy EBRT (N = 77) | 39 Gy EBRT (N = 65) | P value | |
Gender | |||||
Male | 146 (71.2) | 48 (76.2) | 58 (75.3) | 40 (61.5) | 0.11 |
Female | 59 (28.8) | 15 (23.8) | 19 (24.7) | 25 (38.5) | |
Age | |||||
≤70 | 90 (43.9) | 33 (52.4) | 40 (51.9) | 17 (26.2) | <0.01 |
>70 | 115 (56.1) | 30 (47.6) | 37 (48.1) | 48 (73.8) | |
KPS | |||||
90–100 | 40 (19.5) | 13 (20.6) | 17 (22.1) | 10 (15.4) | 0.54 |
60–80 | 140 (68.3) | 40 (63.5) | 52 (67.5) | 48 (73.8) | |
Unknown* | 25 (12.2) | 10 (15.9) | 8 (10.4) | 7 (10.8) | |
Comorbidity | |||||
None to mild | 93 (45.4) | 28 (44.4) | 40 (51.9) | 25 (38.5) | 0.27 |
Moderate to severe | 112 (54.6) | 35 (55.6) | 37 (48.1) | 40 (61.5) | |
Current presentation | |||||
Primary presentation | 171 (83.4) | 50 (79.4) | 64 (83.1) | 57 (87.7) | 0.45 |
Recurrent presentation | 34 (16.6) | 13 (20.6) | 13 (16.9) | 8 (12.3) | |
Symptoms at presentation** | |||||
Dysphagia | 184 (89.8) | 59 (93.7) | 73 (94.8) | 52 (80.0) | |
Pain | 57 (27.8) | 22 (34.9) | 17 (22.1) | 18 (27.7) | |
Weight loss | 149 (72.7) | 53 (84.1) | 53 (68.8) | 43 (66.2) | |
Hematemesis | 5 (2.4) | 3 (4.8) | 0 (0) | 2 (3.1) | |
Other | 53 (25.9) | 15 (23.8) | 22 (28.6) | 16 (24.6) | |
No symptoms | 3 (1.5) | 0 (0) | 0 (0) | 3 (4.6) | |
Dysphagia score before treatment*** | |||||
0–1 | 77 (37.6) | 21 (33.3) | 26 (33.8) | 30 (46.2) | 0.25 |
2–4 | 126 (61.4) | 41 (65.1) | 50 (64.9) | 35 (53.8) | |
Unknown* | 2 (1.0) | 1 (1.6) | 1 (1.3) | 0 (0) | |
Weight loss | |||||
≤6 kg | 103 (50.2) | 26 (41.3) | 38 (49.4) | 39 (60.0) | 0.17 |
>6 kg | 89 (43.4) | 33 (52.4) | 33 (42.9) | 23 (35.4) | |
Unknown* | 13 (6.3) | 4 (6.3) | 6 (7.8) | 3 (4.6) | |
Tube feeding before treatment | |||||
No | 159 (77.6) | 52 (82.5) | 55 (71.4) | 52 (80.0) | 0.18 |
Yes | 44 (21.5) | 11 (17.5) | 22 (28.6) | 11 (16.9) | |
Unknown* | 2 (1.0) | 0 (0) | 0 (0) | 2 (3.1) | |
Tumour length | |||||
≤6 cm | 119 (58.0) | 32 (50.8) | 38 (49.4) | 49 (75.4) | <0.01 |
>6 cm | 85 (41.5) | 31 (49.2) | 38 (49.4) | 16 (24.6) | |
Unknown* | 1 (0.5) | 0 (0) | 1 (1.3) | 0 (0) | |
Tumour location | |||||
High – middle | 39 (19.0) | 6 (9.5) | 18 (23.4) | 15 (23.1) | 0.27 |
Low – GEJ | 142 (69.3) | 46 (73.0) | 51 (66.2) | 45 (69.2) | |
Anastomosis | 10 (4.9) | 4 (6.3) | 4 (5.2) | 2 (3.1) | |
Unknown* | 14 (6.8) | 7 (11.1) | 4 (5.2) | 3 (4.6) | |
Histology | |||||
Adenocarcinoma | 120 (58.5) | 40 (63.5) | 48 (62.3) | 32 (49.2) | 0.03 |
Squamous cell carcinoma | 66 (32.2) | 14 (22.2) | 26 (33.8) | 26 (40.0) | |
Other | 15 (7.3) | 7 (11.1) | 1 (1.3) | 7 (10.8) | |
Unknown* | 4 (2.0) | 2 (3.2) | 2 (2.6) | 0 (0) | |
T stage | |||||
T0–T3 | 61 (29.8) | 15 (23.8) | 21 (27.3) | 25 (38.5) | 0.99 |
T4 | 28 (13.7) | 7 (11.1) | 10 (13.0) | 11 (16.9) | |
Unknown* | 116 (56.6) | 41 (65.1) | 46 (59.7) | 29 (44.6) | |
N stage | |||||
N0 | 31 (15.1) | 4 (6.3) | 5 (6.5) | 22 (33.8) | <0.01 |
N+ | 147 (71.7) | 49 (77.8) | 62 (80.5) | 36 (55.4) | |
Unknown* | 27 (13.2) | 10 (15.9) | 10 (13.0) | 7 (10.8) | |
M stage | |||||
M0 | 69 (33.7) | 7 (11.1) | 15 (19.5) | 47 (72.3) | <0.01 |
M1 | 125 (61.0) | 51 (81.0) | 61 (79.2) | 13 (20.0) | |
Unknown* | 11 (5.4) | 5 (7.9) | 1 (1.3) | 5 (7.7) |
Abbreviations: EBRT, External beam radiotherapy; KPS, Karnofsky performance status; GEJ, Gastroesophageal junction.
The ‘unknown’ categories were not included in calculation of p values.
Total >100% due to possibility of having more than one symptom at presentation. Calculation p value not possible.
Dysphagia score as stated by Knyrim [23]: 0 = no dysphagia/able to eat normal diet, 1 = able to swallow some solid foods, 2 = able to swallow only semi solid foods, 3 = able to swallow liquids only, 4 = total dysphagia.