Table 2.

Changes in gene expression in the pfc, amyg, hpc, and pit after rmtbi, metandienone treatment, and SEC.

Brain region	Gene	Effect of RmTBI F (p)	Effect of met treatment F (p)	Effect of SEC F (p)	Met treatment × RmTBI F (p)	Met Treatment × SEC F (p)	RmTBI × SEC F (p)	Met Treatment × RmTBI × SEC F (p)
PFC	Bdnf	0.30 (0.59)	1.22 (0.28)	8.02 (< 0.01)	0.13 (0.72)	2.15 (0.15)	0.72 (0.40)	0.01 (0.92)
	GR	0.30 (0.59)	5.16 (0.03)	0.14 (0.71)	0.00 (0.99)	1.59 (0.21)	0.15 (0.70)	0.06 (0.81)
	Iba1	0.04 (0.84)	0.05 (0.82)	0.74 (0.39)	0.11 (0.74)	4.10 (0.05)	0.02 (0.89)	0.08 (0.79)
	Maoa	0.00 (0.98)	6.89 (0.01)	8.90 (< 0.01)	0.21 (0.65)	4.02 (0.05)	0.10 (0.75)	0.19 (0.66)
AMYG	Bdnf	1.01 (0.32)	0.94 (0.34)	0.35 (0.56)	0.26 (0.62)	0.32 (0.58)	0.61 (0.44)	4.87 (0.03)
	GR	0.88 (0.35)	0.77 (0.39)	8.43 (< 0.01)	0.00 (0.95)	0.44 (0.51)	4.70 (0.04)	0.84 (0.37)
	Iba1	0.20 (0.66)	1.75 (0.20)	15.94 (<0.01)	0.32 (0.57)	0.01 (0.93)	0.02 (0.90)	0.76 (0.40)
	Maoa	0.44 (0.51)	3.04 (0.09)	8.53 (< 0.01)	0.07 (0.79)	2.14 (0.15)	0.78 (0.38)	0.21 (0.65)
HPC	Bdnf	0.10 (0.75)	1.04 (0.32)	1.25 (0.27)	1.24 (0.27)	0.36 (0.56)	0.43 (0.52)	0.01 (0.92)
	GR	0.00 (0.96)	4.34 (0.04)	1.26 (0.27)	0.24 (0.63)	0.23 (0.63)	0.72 (0.40)	0.01 (0.94)
	Iba1	0.00 (0.98)	0.65 (0.43)	11.18 (< 0.01)	1.17 (0.29)	1.12 (0.30)	0.00 (0.99)	0.59 (0.45)
	Maoa	0.22 (0.64)	1.19 (0.28)	3.20 (0.08)	0.24 (0.63)	0.00 (0.99)	0.56 (0.46)	0.10 (0.75)
PIT	Bdnf	1.01 (0.33)	0.06 (0.81)	0.01 (0.93)	0.41 (0.53)	0.54 (0.47)	0.06 (0.81)	0.01 (0.92)
	ER	0.35 (0.56)	11.02 (< 0.01)	17.58 (< 0.01)	1.21 (0.29)	3.77 (0.07)	0.09 (0.77)	0.00 (0.97)
	GR	0.02 (0.90)	4.44 (0.05)	0.01 (0.93)	0.15 (0.71)	0.262 (0.61)	1.77 (0.20)	0.00 (0.97)
	Iba1	1.37 (0.26)	0.13 (0.73)	7.93 (0.01)	0.42 (0.52)	0.14 (0.72)	0.46 (0.51)	0.07 (0.79)
	Maoa	0.34 (0.57)	3.62 (0.07)	9.61 (< 0.01)	1.67 (0.21)	0.00 (0.96)	0.52 (0.48)	0.02 (0.88)
	Creb	2.38 (0.14)	0.56 (0.46)	5.93 (0.02)	8.16 (0.01)	7.08 (0.01)	0.47 (0.50)	0.02 (0.88)