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. 2019 May 8;10:941. doi: 10.3389/fmicb.2019.00941

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Copyright © 2019 Xie, Wu, Wang, Cheng, Yang, Wu, Jia, Zhu, Zhao, Chen, Liu, Zhang, Wang, Xu, Chen, Zhu, Luo, Liu, Yu, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The structure of virion and the location of the thymidine kinase gene (UL23) in the HSV-1 genome. (A) The virion is mainly composed of four morphologically distinct structures. (B) HSV-1 genomes contain U_L and U_S regions that are each flanked by terminal and internal inverted repeats (TR_L/IR_L and IR_S/TR_S). The UL23 gene is located between UL22 and UL24 in the U_L regions in the same orientation as the UL22 gene and the opposite orientation from the UL24 gene.