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. 2019 May 14;9:7354. doi: 10.1038/s41598-019-43669-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the measurement of cell-biomaterial interaction forces by colloidal probe microscopy. A biomaterial-coated colloidal probe and a substrate with living cells are approached each other (A) until contact (B), and then they are retracted (C) until detachment. The interaction forces are quantified from the deflection of the cantilever, which is monitored with a laser and a photodetector. Figure prepared by Joel Wolff.