Table 1.
Summary of mouse phenotypes of lung tumors and lungs
| Genotype | No. | Age (Month) | The percent (%) of phenotypes in mouse lungs | |||||
|---|---|---|---|---|---|---|---|---|
| SCC-DS | SCC | SCC-DS + SCC | AD-DS | AD | AD-DS + AD | |||
| Lkb1 d/d | 56 | 11–14 | 25.0 | 16.1 | 32.8 | 16.1 | 37.5 | 53.6 |
| Pten d/d | 12 | 12–13 | 0 | 0 | 0 | 16.7 | 8.3 | 25.0 |
| P53 d/d | 10 | 12–13 | 0 | 0 | 0 | 10.0 | 10.0 | 20.0 |
| Mig6 d/d | 12 | 9 | 0 | 0 | 0 | 8.3 | 0 | 8.3 |
| Kras G12D | 8 | 1 | 0 | 0 | 0 | 100 | 37.5 | 100 |
| Smad4 d/d | 9 | 11–13 | 0 | 0 | 0 | 0 | 0 | 0 |
| WT | 25 | 1–14 | 0 | 0 | 0 | 4.0 | 0 | 4.0 |
Lkb1d/d: CCSPiCre Lkb1f/f; Ptend/d: CCSPiCrePtenf/f; P53d/d: CCSPiCrep53f/f; Mig6d/d: CCSPiCreMig6f/f; KrasG12D: CCSPiCreKrasG12D; Smad4d/d: CCSPiCreSmad4f/f; WT wild type. SCC development stages include epithelial hyperplasia, epithelial hyperplasia with squamous metaplasia, adenocarcinoma with squamous differentiation and adenosquamous carcinoma
Adenocarcinoma development stages include epithelial hyperplasia and adenoma
SCC squamous cell carcinoma, DS development stage, AD adenocarcinoma, No. number