Table 2.
Analysis of enriched upstream regulators and its core downstream pathways
| Top upstream regulators | P value of overlap | Core downstream pathways of TNF and IL1B |
|---|---|---|
| TGFB1 | 4.32E-41 | JNK1/2 pathway |
| TNF | 7.04E-39 | p38 pathway |
| TP53 | 2.13E-28 | NFĸB pathway |
| ERBB2 | 3.54E-26 | ERK1/2 pathway |
| IL1B | 7.85E-22 |
Top enriched upstream regulators were identified from these differentially expressed genes identified in the microarray (13-month-old (13M) Lkb1d/d mouse lung SCCs vs. 13M Lkb1f/f mouse lungs; Supplementary Data 3) using ingenuity pathway analysis (IPA)
SCC squamous cell carcinoma