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. 2019 Apr 19;14:94–106. doi: 10.1016/j.omto.2019.04.002

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© 2019 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Silencing LGR6 Inhibits Wnt/β-Catenin Signaling

(A) GSEA analysis showed that LGR6 expression level was positively correlated with Wnt/β-catenin signaling. (B) Western blot analysis of total and nuclear expression of β-catenin in the indicated cells. p84 was used as loading control. (C) The TOP/FLASH reporter activity in the indicated ovarian cancer cells. Error bars represent the mean ± SD of three independent experiments. *p < 0.05. (D) Real-time PCR analysis of TCF1, LEF1, VEGFA, MMP7, CCND1, DDK3, and CDH1 in the indicated cells.