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. 2019 Apr 19;14:94–106. doi: 10.1016/j.omto.2019.04.002

Figure 7.

Figure 7

Silencing LGR6 Represses Stemness and Chemoresistance via Inhibiting Wnt/β-Catenin Signaling

(A) S33Y reversed the inhibitory effects of LGR6 silencing on activity of Wnt/β-catenin signaling. Error bars represent the mean ± SD of three independent experiments. *p < 0.05. (B–D) S33Y reversed the inhibitory effects of LGR6 silencing on spheroid formation ability (B) and SP+ (C) and CD133+ (D) populations of ovarian cancer cells. Error bars represent the mean ± SD of three independent experiments. *p < 0.05. (E) S33Y reversed the inhibitory effects of LGR6 silencing on chemoresistance of ovarian cancer cells to cisplatin and paclitaxel. Error bars represent the mean ± SD of three independent experiments. *p < 0.05.