Table 1.
Cancer-Related circRNAs
| Cancer | circRNA | Function | Signal Path | Effect |
|---|---|---|---|---|
| Gastric cancer55, 56 | circPVT1 | miRNA sponge | miR-125 | regulates cell proliferation; potential biomarker |
| circ-LARP4 | miRNA sponge | miR-424-5p | ||
| CDR1as | miRNA sponge | miR-7 | anticancer | |
| circ-Foxo3 | binds to protein | p21 and CDK2 proteins | regulates cell cycle progression | |
| Human hepatocellular carcinoma (HCC)52, 57, 58, 59, 60, 61 | circZKSCAN1 | inhibits proliferation, migration, and invasion | ||
| CDR1as | miRNA sponge | miR-7 | a risk factor | |
| hsa-circ-0001649 | potential biomarker | |||
| circRNA-100269 | miRNA sponge | miR-630 | inhibits proliferation | |
| hsa-circ-002059 | potential biomarker | |||
| circHIPK3 | miRNA sponge | regulates proliferation | ||
| hsa-circ-100338 | miRNA sponge | miR-141-3p | associated with tumor metastasis and prognosis | |
| circ-MT01 | miRNA sponge | miR-9 | promotes p21 expression; suggests a poor prognosis | |
| Colorectal cancer62, 63 | circ-CCDC66 | promotes proliferation, migration, and invasion | ||
| hsa-circ-0000069 | promotes proliferation, migration, and invasion | |||
| hsa-circ-001569 | miRNA sponge | miR-145 | a positive regulator of proliferation and invasion | |
| circ-ITCH | miRNA sponge | miR-7, miR-20 s | inhibits proliferation | |
| hsa-circ-001988 | potential biomarker | |||
| Esophageal squamous cell carcinoma64, 65 | hsa-circ-0067934 | miRNA sponge | miR-214, miR-98 | promotes proliferation |
| circ-ITCH | miRNA sponge | miR-17, miR-214 | inhibits proliferation | |
| hsa-circ-001059 | miRNA sponge | potential biological function in tumor radiotherapy resistance | ||
| Breast cancer65, 66 | CDR1as | miRNA sponge | miR-7 | inhibits proliferation |
| circ-ABCB10 | miRNA sponge | miR-1271 | promotes proliferation | |
| hsa-circ-0001785 | potential biomarker | |||
| Lung cancer65, 67, 68 | CDR1as | miRNA sponge | miR-7 | inhibits proliferation |
| circ-ITCH | miRNA sponge | miR-214 | inhibits proliferation | |
| hsa-circ-0043256 | miRNA sponge | miR-1252 | inhibits proliferation; induces apoptosis | |
| circEA1 | associated with cell differentiation and drug resistance | |||
| circRNA-100876 | potential biomarker | |||
| Bladder cancer54, 69, 70 | circTCF25 | miRNA sponge | miR-103a-3p, miR-107 | promotes proliferation and migration |
| circPTK2 | promotes proliferation and migration; potential biomarker |