TABLE E3.

Discriminant validity: Difference in MSD by presence or absence of clinical factors at all visits

		Absence of factor		Presence of factor
Factor	Visit	N	MSD, median (IQR)	N	MSD, median (IQR)	P value
Poor control on ACT/C-ACT	Baseline	147	1 (0–3)	199	4 (2–10)	<.001
	6 mo	189	0 (0–2)	132	4 (2–7.5)	<.001
	12 mo	193	0 (0–2)	113	4 (2–12)	<.001
Poor control on ATAQ-Control	Baseline	123	1 (0–3)	277	4 (2–8)	<.001
	3 mo	201	1 (0–3)	142	4 (3–8)	<.001
	6 mo	203	0 (0–2)	121	4 (2–8)	<.001
	9 mo	201	0 (0–3)	125	4 (3–10)	<.001
	12 mo	196	0 (0–3)	110	4 (2–8)	<.001
Need for acute care in previous 3 mo	Baseline	116	2 (0–4)	234	3 (1–8)	<.001
	3 mo	248	2 (0–4)	98	3 (1–7)	<.001
	6 mo	223	1 (0–4)	101	3 (0–7)	<.001
	9 mo	239	2 (0–3)	87	4 (2–14)	<.001
	12 mo	224	1 (0–3)	84	4 (1–8.5)	<.001
Need for oral steroids in previous 3 mo	Baseline	185	2 (0–5)	165	3 (1–8)	.005
	3 mo	264	2 (0–4)	82	3 (1–7)	<.001
	6 mo	246	1 (0–4)	78	3.5 (1–7)	.005
	9 mo	249	2 (0–3)	77	3 (2–7)	.002
	12 mo	254	1 (0–4)	54	4 (1–10)	<.001
Need for rescue inhaler in previous 2 wk	Baseline	83	0 (0–3)	267	3 (1–7)	<.001
	3 mo	104	0 (0–2)	240	3 (2–7)	<.001
	6 mo	115	0 (0–2)	209	3 (1–6)	<.001
	9 mo	107	0 (0–0)	77	3 (2–7)	<.001
	12 mo	107	0 (0–1)	54	3 (1–7)	<.001