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Overview of potential physiological consequences following the presence of plasma free hemoglobin in a biological treatment vial.
| Radical oxygen reactions [51] Oxidative stress [51,52] Local vasoconstriction [52,55] Pro-inflammation [51,55,56,68] Impaired cell metabolism [51,55,56] Tissue damage [59] Inflammatory infiltrates [60] Ceramide release [45,63] Endothelial cell dysfunction [54,57,59] Vascular damage [63,64,65] Eryptosis [46,61] Mesenchymal stem cell dysfunction [72] Pain [73] |
