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. 2019 May 8;10:282. doi: 10.3389/fendo.2019.00282

Table 2.

ART outcomes in low responder women.

Variable FSH hMG FSH+LH p-value
Number of cycles n (%) 623 (61.9%) 164 (16.3%) 219 (21.8%)
Female Age (years) 38.00 ± 3.45 38.74 ± 3.35 38.74 ± 2.96 0.002
Male Age (years) 40.01 ± 5.38 41.10 ± 6.45 40.36 ± 4.77 0.070
Basal FSH (IU/L) 9.01 ± 3.97 9.61 ± 3.99 9.57 ± 3.91 0.083
Basal LH (IU/L) 5.36 ± 2.75 5.09 ± 2.05 6.11 ± 2.47 0.019
AMH (ng/mL) ± 1.16 0.69 ± 0.76 0.66 ± 0.82 < 0.001
AFC 6.29 ± 4.68 5.58 ± 3.52 4.80 ± 2.44 < 0.001
Total FSH doses (IU/L) 3,893 ± 1,375 3,621 ± 1,289 3,269 ± 1,046 < 0.001
Total LH dose (IU/L) 0 0 1,484 ± 575 < 0.001
FSH dose/oocytes ratio 1,944 ± 1,276 1,847 ± 1,069 1,555 ± 825 < 0.001
Oocytes retrieved 2.36 ± 0.73 2.27 ± 0.74 2.37 ± 0.69 0.327
MII oocytes 1.78 ± 0.91 1.84 ± 0.85 1.86 ± 0.86 0.481
MII oocytes/oocytes retrieved 0.75 ± 0.32 0.80 ± 0.29 0.78 ± 0.30 0.099
Injected oocytes 1.76 ± 0.94 1.81 ± 0.88 1.84 ± 0.87 0.488
Frozen oocytes 0.01 ± 0.17 0.02 ± 0.17 0 0.495
Fertilized oocytes 1.31 ± 0.94 1.20 ± 0.90 1.41 ± 0.89 0.075
Cumulative embryos 1.25 ± 0.91 1.16 ± 0.88 1.34 ± 0.86 0.149
Transferred embryos 1.22 ± 0.90 1.212 ± 0.87 1.32 ± 0.87 0.084
Frozen embryos 0.03 ± 0.22 0.04 ± 0.23 0.01 ± 0.12 0.418
Implantation rate 10.05 ± 27.00 9.38 ± 25.08 13.48 ± 29.68 0.305
Biochemical pregnancies n (%) 65 (10.4%) 17 (10.4%) 35 (16.0%) 0.186
Deliveries n (%) 40 (6.4%) 11 (6.7%) 21 (9.6%) 0.948
Miscarriage n (%) * 24 (3.8%) 6 (3.7%) 14 (6.4%) 0.921
Miscarriage n (%)** 24 (36.9%) 6 (35.3%) 14 (40.0%)
Ectopic pregnancies n (%)* 1 (0.2%) 0 (0%) 0 (0%) 0.978
Ectopic pregnancies n (%)** 1 (1.5%) 0 (0%) 0 (0%)

Data are expressed as mean ± standard deviation or number (percentage).

*

% Considering the total number of cycles.

**

% Considering the number of clinical pregnancies.

Bold values, represent statistical significant p-values.