Table 3.
Prospective change in key metabolic factors based on ALT quartiles and resolution of fatty liver in men.
| Q1 5–24 IU/L (n = 7294) | Q2 25–33 IU/L (n = 7633) | Q3 34–48 IU/L (n = 8062) | Q4 ≥ 49 IU/L (n = 7999) | |||||
|---|---|---|---|---|---|---|---|---|
| Resolved (n = 1901) |
Persisted (n = 5393) |
Resolved (n = 1548) |
Persisted (n = 6085) |
Resolved (n = 1253) |
Persisted (n = 6809) |
Resolved (n = 767) |
Persisted (n = 7232) |
|
| BMI change | −0.59 ± 1.18 (−0.64, −0.54) | 0.40 ± 1.10 1 (0.37, 0.43) | −0.98 ± 1.22 (−1.04, −0.92) | 0.27 ± 1.10 1 (0.24, 0.3) | −1.29 ± 1.49 (−1.37, −1.21) | 0.14 ± 1.14 1 (0.11, 0.16) | −1.75 ± 1.66 (−1.87, −1.63) | 0.02 ± 1.27 1 (−0.01, 0.05) |
| Glucose change | 0.97 ± 12.75 (0.39, 1.54) | 2.23 ± 11.38 1 (1.93, 2.54) | 0.48 ± 10.01 (−0.02, 0.98) | 2.96 ± 11.06 1 (2.69, 3.24) | 2.05 ± 12.96 (1.33, 2.77) | 3.66 ± 13.5 1 (3.34, 3.98) | 1.20 ± 16.19 (0.06, 2.35) | 5.13 ± 18.06 1 (4.71, 5.54) |
| LDL-C change | 4.17 ± 23.21 (3.11, 5.22) | 9.34 ± 22.42 1 (8.74, 9.94) | 1.07 ± 24.21 (−0.14, 2.29) | 7.97 ± 23.81 1 (7.37, 8.58) | −0.56 ± 26.28 (−2.03, 0.92) | 6.09 ± 24.09 1 (5.52, 6.67) | −4.59 ± 28.49 (−6.62, −2.55) | 2.46 ± 24.51 1 (1.89, 3.03) |
| TG change | −13.91 ± 74.08 (−17.24, −10.58) | 11.33 ± 81.03 1 (9.17, 13.5) | −25.51 ± 74.97 (−29.24, −21.77) | 7.66 ± 84.49 1 (5.53, 9.78) | −34.92 ± 85.49 (−39.66, −30.18) | 1.21 ± 91.06 1 (−0.96, 3.37) | −49.66 ± 88.74 (−55.95, −43.37) | −4.03 ± 98.31 1 (−6.3, −1.77) |
| HDL-C change | 2.50 ± 8.68 (2.11, 2.89) | −0.66 ± 7.38 1 (−0.86, −0.46) | 3.07 ± 8.78 (2.63, 3.5) | −0.86 ± 7.49 1 (−1.05, −0.68) | 2.94 ± 9.26 (2.42, 3.45) | −0.9 ± 7.42 1 (−1.08, −0.73) | 3.17 ± 9.15 (2.52, 3.82) | −1.1 ± 7.42 1 (−1.27, −0.93) |
| AST change | 0.20 ± 7.45 (−0.13, 0.54) | 2.59 ± 9.97 1 (2.32, 2.85) | −1.74 ± 16.11 (−2.55, −0.94) | 1.49 ± 18.35 1 (1.02, 1.95) | −5.44 ± 10.18 (−6, −4.88) | −0.5 ± 12.54 1 (−0.8, −0.2) | −15.53 ± 22.19 (−17.1, −13.96) | −7.66 ± 20.84 1 (−8.14, −7.18) |
| ALT change | 0.34 ± 8.82 (−0.06, 0.73) | 6.47 ± 14.68 1 (6.08, 6.86) | −5.97 ± 9.48 (−6.44, −5.5) | 3.80 ± 17.54 1 (3.36, 4.24) | −13.72 ± 13.67 (−14.48, −12.96) | −0.84 ± 21.05 1 (−1.34, −0.34) | −38.29 ± 35.23 (−40.78, −35.79) | −20.12 ± 36.38 1 (−20.96, −19.28) |
| hs-CRP change | 0.015 ± 0.52 (−0.02, 0.05) | 0.012 ± 0.4 (−0.002, 0.03) | −0.010 ± 0.33 (−0.03, 0.01) | 0.001 ± 0.44 (−0.01, 0.02) | 0.042 ± 0.88 (−0.03, 0.11) | 0.006 ± 0.38 (−0.01, 0.02) | −0.011 ± 0.51 (−0.06, 0.04) | 0.001 ± 0.37 (−0.01, 0.01) |
Data are mean ± standard deviation. Change was calculated as BMIfollow-up−BMIbaseline. 1 p < 0.05 between individuals who resolved and persisted using independent t-tests. ALT = alanine aminotransferase, AST = aspartate transaminase, BMI = body mass index, HDL-C = high-density lipoprotein cholesterol, hs-CRP = high-sensitivity c-reactive protein, LDL-C = low-density lipoprotein cholesterol, TG = triglyceride.