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. 2019 Apr 11;8(4):496. doi: 10.3390/jcm8040496

Table 2.

Baseline measures of cardiac and peripheral autonomic control evaluated by linear and nonlinear approaches.

Rest_tVNS off (n = 13) Rest_tVNS on (n = 13) P
Linear Analysis
R–R interval
HR (beats/min) 66 (61–68) 63 (60–66) <0.01
Variance (ms2) 2572 (1494–4291) 2549 (1717–3331) 0.54
VLF abs. (ms2) 1146 (580–1475) 1132 (485–1439) 0.98
LF n.u. (%) 41 (19–62) 53 (28–63) 0.27
HF n.u. (%) 57 (35–71) 46 (35–69) 0.45
LF/HF 0.7 (0.3–1.9) 1.2 (0.4–1.8) 0.50
Systolic Arterial Pressure
Variance (mmHg2) 19 (8–27) 13 (6–19) <0.01
LF abs. (mmHg2) 1.0 (0.6–2.2) 1.4 (0.6–2.8) 0.37
Respiratory Rate
HF (Hz) 0.29 (0.20–0.33) 0.29 (0.26–0.31) 0.73
Nonlinear Analysis
R–R interval patterns
0V (%) 18 (8–27) 17 (5–20) <0.01
1V (%) 45 (44–52) 49 (43–52) 0.24
2LV (%) 11 (7–22) 12 (10–20) 0.95
2UV (%) 21 (11–32) 25 (16–33) 0.31
Systolic Arterial Pressure Pattern
0V (%) 36 (14–47) 17 (13–30) <0.01

Median (25th–75th). tVNS = transcutaneous vagus nerve stimulation; HR = heart rate; VLF = very low frequency; LF = low frequency; HF = high frequency; LF/HF = sympathovagal balance; n.u. = normalized unit, ω = central frequency.