Table 3.
The clinical course of patients with BKVN.
| Patient No. | Sex/Age at BKVN (yr) | Primary Disease |
Transplant Year/Donor Type |
Onset of Viremia after KT |
Initial Level 1 (Copies/mL) |
Peak Level 2 (Copies/mL) |
Biopsy Grade |
Treatment | Follow up after BKVN |
Time to Viremia Clearance |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F/8.0 | ATN | 2009/D | 1.5 mo | 16,924 | 10,165,852 | B1 | Reduction of IS, IVIG, leflunomide | 8.3 yr | 89.9 mo |
| 2 | F/20.6 | Alport | 2010/D | 60.3 mo | 289,699 | 289,699 | B3 | Reduction of IS, IVIG, leflunomide | 3.0 yr | No |
| 3 | M/13.1 | Alport | 2010/L | 24.0 mo | 41,914 | 41,914 | B1 | Reduction of IS, IVIG, leflunomide | 6.4 yr | No |
| 4 | M/15.0 | Alport | 2014/L | 15.9 mo | 68,919 | 2,266,980 | B1 | Reduction of IS, IVIG, leflunomide, ciprofloxacin, cidofovir | 2.2 yr | No |
| 5 | F/16.8 | FSGS | 2014/L | 4.6 mo | 51,102 | 322,854 | ND | Reduction of IS, leflunomide, ciprofloxacin | 3.8 yr | 16.6 mo |
| 6 | M/19.5 | FSGS | 2015/D | 6.0 mo | 25,555 | 62,481 | ND | Reduction of IS, leflunomide | 2.4 yr | 20.5 mo |
1 The value of BK virus load when BK viremia was first detected. 2 The highest value of BK virus load. Abbreviations: BKVN: BK virus nephropathy; S-Cr: serum creatinine; ATN: acute tubular necrosis; VUR: vesicoureteral regurgitation; FSGS: focal segmental glomerulosclerosis; D: deceased; L: living; ND: not done; IS: immunosuppressant; IVIG: intravenous immunoglobulin; mo: months; yr: year.