Table 5.

Adverse reactions to EE-TP administration in Patient 1.

Infusion #	Observations	Pre-Medication Prior to Infusion
2	nausea felt hot and faint erythema of face, neck and in arm proximal to infusion site tickle sensation in throat subsided spontaneous after 5 min	None
3	coughing spasm sensation in throat described as a tickle dry mouth felt hot subsided spontaneously after 5 min	Oral chlorphenamine 4 mg 3 h prior
4	coughing spasm	Oral chlorphenamine 8 mg 3 h prior
5	generalized paresthesia nausea coughing spasm generalized erythema transient headache, visual disturbance subsided spontaneously after 5 min	Oral chlorphenamine 8 mg 3 h prior IV hydrocortisone 50 mg at time of reaction
6	no reactions	Oral dexamethazone 4 mg 6 h prior Oral chlorphenamine 8 mg 3 h prior IV maxalon 10 mg immediately prior to infusion
9	coughing spasm nausea felt hot	As infusion 6
10	nausea	Oral dexamethazone 4 mg 6 h prior Oral chlorphenamine 8 mg 3 h prior Oral ondansetron 4 mg 3 h prior
15	coughing spasm nausea felt cold and shaky	As infusion 10
17	coughing spasm nausea erythema of neck	Oral dexamethazone 8 mg 6 h prior Oral chlorphenamine 12 mg in two divided doses: 6 h (8 mg) and 2 h (25%) prior Oral ondansetron 8 mg 3 h prior
18–31	no reactions	Oral dexamethazone 10 mg 6 h prior Oral chlorphenamine 12 mg two divided doses: 6 h (8 mg) and 2 h (4 mg) prior Oral ondansetron 16 mg total in two equal doses, 6 and 3 h prior