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. 2019 Apr 15;8(4):513. doi: 10.3390/jcm8040513

Figure 4.

Figure 4

C1QBP expression pattern and patient survival analysis in colon cancer: comparison of C1QBP expression in normal tissue and cancer tissue. (a) The fold-change of C1QBP in colon cancers was identified by our analyses, represented as a box plot. The box plot comparing specific C1QBP expression in normal (n = 18, left plot) and cancer tissue (n = 18, right plot) was derived from the Oncomine database. The analysis was performed in COAD in comparison to normal colon. The asterisk above and below the box represent maximum and minimum value, respectively. (b) Expression of C1QBP gene in the Cancer Genome Atlas (TCGA) database. Box plots showing the C1QBP mRNA expression in COAD tumors (T, red plot) and the respective normal (N, gray/blue plot) tissues, using data from the TCGA database through TCGA Wanderer and Gene Expression Profiling Interactive Analysis (GEPIA). *: p < 0.01. (c) Alterations (mRNA upregulation/downregulation) of the C1QBP gene in COAD (TCGA PanCanAtlas; n = 439). Data was obtained using cBioPortal. (d) C1QBP mRNA expression was significantly associated with the copy number alteration status (ANOVA, p < 0.0001) in colon cancer. (****: p < 0.0001; ns: nonsignificant). (e) The survival curve comparing patients with high (red) and low (blue) expression in colon cancer was plotted from the PrognoScan database. Survival curve analysis was conducted using a threshold Cox p-value < 0.05. Abbreviations. COAD: colon adenocarcinoma; MACR: mucinous adenocarcinoma of the colon and rectum; RAD: rectal adenocarcinoma; CA: colorectal adenocarcinoma.