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. 2016 Sep 15;59(12):2686–2696. doi: 10.1007/s00125-016-4104-3

Table 4.

Fasting skeletal muscle gene expression

Gene Mild-IR High-IR p valuea Total group SE β p valueb
Oxidative metabolism n = 32 n = 30
   mCPT1B 1.70 ± 0.14 1.74 ± 0.13 0.821 0.006 0.986
   PGC1α (PPARGC1A) 0.51 ± 0.05 0.46 ± 0.04 0.428 0.027 0.847
   ACC2 1.52 ± 0.14 1.59 ± 0.16 0.741 0.020 0.891
   SDHB 2.40 ± 0.21 1.97 ± 0.22 0.153 −0.058 0.683
   NDUFB5 2.67 ± 0.17 2.14 ± 0.23 0.062 −0.243 0.076
Transcription factors n = 28 n = 23
   PPARα (PPARA) 1.63 ± 0.16 1.56 ± 0.11 0.743 0.034 0.808
   PPARδ (PPARD) 0.36 ± 0.04 0.48 ± 0.07 0.114 0.175 0.259
   SREBP1c (SREBF1) 0.92 ± 0.10 1.12 ± 0.14 0.238 0.028 0.840
   SREBP2 (SREBF2) 1.43 ± 0.15 1.86 ± 0.23 0.127 0.266 0.216
   ChREBP (CREBBP) 1.02 ± 0.19 0.99 ± 0.15 0.906 −0.040 0.859
TAG synthesis n = 10 n = 15
   GPAT1 (GPAM) 2.55 ± 0.23 1.81 ± 0.25 0.050 −0.666 0.002
   DGAT1 1.89 ± 0.19 1.77 ± 0.20 0.667 0.079 0.683
   DGAT2 0.31 ± 0.05 0.25 ± 0.06 0.509 −0.103 0.671
TAG lipolysis n = 15 n = 8
   LPL 0.50 ± 0.08 0.62 ± 0.11 0.342 0.018 0.927
   ATGL (PNPLA2) 1.11 ± 0.17 2.52 ± 0.60 0.052 0.522 0.007
   HSL (LIPE) 0.44 ± 0.19 0.74 ± 0.21 0.329 0.130 0.515

Values are presented as mean ± SEM

The italic entries are all gene symbols

a p value for difference between mild-IR and high-IR group, Student’s t test for unpaired samples

b p value for multiple linear regression

mCPT1b, muscle CPT1B; SE β, standardised β coefficient for HOMA-IR, adjusted for sex and BMI