Table 4.
Gene | Mild-IR | High-IR | p valuea | Total group SE β | p valueb |
---|---|---|---|---|---|
Oxidative metabolism | n = 32 | n = 30 | |||
mCPT1B | 1.70 ± 0.14 | 1.74 ± 0.13 | 0.821 | 0.006 | 0.986 |
PGC1α (PPARGC1A) | 0.51 ± 0.05 | 0.46 ± 0.04 | 0.428 | 0.027 | 0.847 |
ACC2 | 1.52 ± 0.14 | 1.59 ± 0.16 | 0.741 | 0.020 | 0.891 |
SDHB | 2.40 ± 0.21 | 1.97 ± 0.22 | 0.153 | −0.058 | 0.683 |
NDUFB5 | 2.67 ± 0.17 | 2.14 ± 0.23 | 0.062 | −0.243 | 0.076 |
Transcription factors | n = 28 | n = 23 | |||
PPARα (PPARA) | 1.63 ± 0.16 | 1.56 ± 0.11 | 0.743 | 0.034 | 0.808 |
PPARδ (PPARD) | 0.36 ± 0.04 | 0.48 ± 0.07 | 0.114 | 0.175 | 0.259 |
SREBP1c (SREBF1) | 0.92 ± 0.10 | 1.12 ± 0.14 | 0.238 | 0.028 | 0.840 |
SREBP2 (SREBF2) | 1.43 ± 0.15 | 1.86 ± 0.23 | 0.127 | 0.266 | 0.216 |
ChREBP (CREBBP) | 1.02 ± 0.19 | 0.99 ± 0.15 | 0.906 | −0.040 | 0.859 |
TAG synthesis | n = 10 | n = 15 | |||
GPAT1 (GPAM) | 2.55 ± 0.23 | 1.81 ± 0.25 | 0.050 | −0.666 | 0.002 |
DGAT1 | 1.89 ± 0.19 | 1.77 ± 0.20 | 0.667 | 0.079 | 0.683 |
DGAT2 | 0.31 ± 0.05 | 0.25 ± 0.06 | 0.509 | −0.103 | 0.671 |
TAG lipolysis | n = 15 | n = 8 | |||
LPL | 0.50 ± 0.08 | 0.62 ± 0.11 | 0.342 | 0.018 | 0.927 |
ATGL (PNPLA2) | 1.11 ± 0.17 | 2.52 ± 0.60 | 0.052 | 0.522 | 0.007 |
HSL (LIPE) | 0.44 ± 0.19 | 0.74 ± 0.21 | 0.329 | 0.130 | 0.515 |
Values are presented as mean ± SEM
The italic entries are all gene symbols
a p value for difference between mild-IR and high-IR group, Student’s t test for unpaired samples
b p value for multiple linear regression
mCPT1b, muscle CPT1B; SE β, standardised β coefficient for HOMA-IR, adjusted for sex and BMI