Table 1.

Clinical characteristics of cohort 1

	Before weight loss (A)	After weight loss (B)	Non-obese controls (C)	p value
				A vs B	A vs C
Age (years)	44 ± 9	46 ± 9	47 ± 11		0.307
BMI (kg/m2)	42.3 ± 4.8	28.3 ± 4.5	24.7 ± 2.2	<0.001	<0.001
Waist circumference (cm)	129 ± 10.8	95.5 ± 12.6	86 ± 7.0	<0.001	<0.001
Waist-to-hip ratio	1.00 ± 0.06	0.92 ± 0.07a	0.87 ± 0.06	<0.001	<0.001
P-glucose (mmol/l)	5.7 ± 1.5	4.9 ± 0.6b	5.0 ± 0.4	<0.001	0.025
P-insulin (pmol/l)	16.5 ± 9.31	4.63 ± 1.87c	3.88 ± 1.57	<0.001	<0.001
P-triacylglycerols (mmol/l)	1.63 ± 0.81d	1.01 ± 0.49	0.92 ± 0.63	<0.001	<0.001
Total cholesterol (mmol/l)	4.8 ± 0.9	4.2 ± 0.9	5.0 ± 1.2	<0.001	0.729
HDL-cholesterol (mmol/l)	1.1 ± 0.2	1.5 ± 0.4	1.6 ± 0.4	<0.001	<0.001
LDL-cholesterol (mmol/l)	3.3 ± 0.8e	2.5 ± 0.7	3.1 ± 1.0f	<0.001	0.112
ApoA-I (g/l)	1.20 ± 0.19	1.42 ± 0.33	1.45 ± 0.23	<0.001	<0.001
ApoB (g/l)	0.95 ± 0.24	0.81 ± 0.21	0.90 ± 0.28	0.001	0.363
Clamp (mmol glucose kg−1 body weight min−1)	0.0202 ± 0.0066g	0.0369 ± 0.0075b	0.0439 ± 0.0090	<0.001	<0.001
HOMA-IR	4.30 ± 2.93	1.00 ± 0.43b	0.85 ± 0.37b	<0.001	<0.001
Subjects (n)	37	37	19

Data represent value ± SD

^a n = 36; ^b n = 33; ^c n = 32; ^d n = 36; ^e n = 36; ^f n = 18; ^g n = 33

Apo, apolipoprotein; P, fasting plasma