Table 2.
Genotype distributions of H19 gene polymorphisms in 431 controls and 431 patients with UCC.
| Variable | Controls (N = 431) n (%) |
Patients (N = 431) n (%) |
OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
| rs2177727 | ||||
| CC | 191 (44.3%) | 185 (42.9%) | 1.000 (reference) | 1.000 (reference) |
| CT | 188 (43.6%) | 202 (46.9%) | 1.109 (0.836–1.473) | 1.072 (0.784–1.467) |
| TT | 52 (12.1%) | 44 (10.2%) | 0.874 (0.557–1.369) | 0.758 (0.458–1.255) |
| CT+TT | 240 (55.7%) | 246 (57.1%) | 1.058 (0.808–1.385) | 1.002 (0.744–1.350) |
| rs2107425 | ||||
| CC | 171 (39.7%) | 152 (35.3%) | 1.000 (reference) | 1.000 (reference) |
| CT | 190 (44.1%) | 213 (49.4%) | 1.261 (0.941–1.691) | 1.245 (0.901–1.721) |
| TT | 70 (16.2%) | 66 (15.3%) | 1.061 (0.710–1.584) | 0.978 (0.625–1.529) |
| CT+TT | 260 (60.3%) | 279 (64.7%) | 1.207 (0.916–1.591) | 1.172 (0.865–1.589) |
| rs2839698 | ||||
| CC | 192 (44.5%) | 206 (47.8%) | 1.000 (reference) | 1.000 (reference) |
| CT | 184 (42.7%) | 170 (39.4%) | 0.861 (0.647–1.147) | 0.907 (0.660–1.247) |
| TT | 55 (12.8%) | 55 (12.8%) | 0.932 (0.611–1.422) | 0.881 (0.555–1.399) |
| CT+TT | 239 (55.5%) | 225 (52.2%) | 0.877 (0.671–1.147) | 0.901 (0.669–1.212) |
| rs3024270 | ||||
| CC | 120 (27.8%) | 114 (26.5%) | 1.000 (reference) | 1.000 (reference) |
| GC | 208 (48.3%) | 210 (48.7%) | 1.063 (0.772–1.464) | 1.316 (0.920–1.884) |
| GG | 103 (23.9%) | 107 (24.8%) | 1.094 (0.753–1.587) | 1.189 (0.786–1.797) |
| GC+GG | 311 (72.2%) | 317 (73.5%) | 1.073 (0.795–1.449) | 1.271 (0.909–1.778) |
| rs3741219 | ||||
| AA | 185 (42.9%) | 192 (44.5%) | 1.000 (reference) | 1.000 (reference) |
| GA | 190 (44.1%) | 181 (42%) | 0.918 (0.689–1.223) | 0.978 (0.711–1.345) |
| GG | 56 (13%) | 58 (13.5%) | 0.998 (0.656–1.517) | 0.912 (0.576–1.444) |
| GA+GG | 246 (57.1%) | 239 (55.5%) | 0.936 (0.715–1.225) | 0.962 (0.713–1.296) |
Bold font indicates statistical significance (p < 0.05). The odds ratio (OR) with their 95% confidence intervals (CI) were estimated by logistic regression models. The adjusted odds ratio (AOR) with their 95% CI were estimated by multiple logistic regression models after controlling for age, sex, and tobacco consumption.