Figure 1.

Equation for disease specific cost-savings estimate. Variable definitions by factor. Factor 1: b = all direct costs without condition specific treatment; i = all direct costs with a range from condition specific average treatment cost (i₁) to cost-efficient treatment (i₂). Factor 2: ΔP = P_H − P_L; net cost of condition progression (P_H = all direct costs when treated high severity, P_L = all direct costs when treated low severity); t = time of condition progression. Factor 3: E = high-cost event probability without condition specific treatment; e = high-cost event probability with condition specific average treatment; c = average high-cost event cost. Factor 4: a = treatment adherence savings. The resulting condition specific cost savings are per affected patient, per year.