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Meta-analysis of observational studies on composite effectiveness outcomes stratified by DOAC, then grouped by age band and DOAC dose. HS = haemorrhagic stroke, ICH = intracranial haemorrhage, IS = ischaemic stroke, RI = retinal infarct, SE = systemic embolism, TIA = transient ischaemic attack, and US = unspecified stroke. Effect sizes reported are hazard ratio. Sex is male and female unless otherwise stated.
