Table 1.
A subset1 of gene ontology (GO) enrichment of consensus ROH analysis, and annotated genes in (a) East- and North-African populations, (b) East-African populations, and (c) North-African populations.
| GO:Term | GO:ID | Genes |
|---|---|---|
| (a) East- (Rwanda–Uganda) and North-African (Dandarawi and Fayoumi) populations | ||
| Alpha-amylase activity | GO:0004556 | AMY2A |
| Calcium ion binding | GO:0005509 | SLC25A24 |
| Cellular response to oxidative stress | GO:0034599 | SLC25A24 |
| (b) East-African (Rwanda–Uganda) populations | ||
| Angiogenesis | GO:0001525 | VASH1, Ang, ANGPT-1, ANGPT-2B, PGF |
| Glutathione transferase activity | GO:0004364 | GSTZ1 |
| Heme binding. | GO:0020037 | NGB |
| Oxygen binding | GO:0019825 | NGB |
| Oxygen transport | GO:0015671 | NGB |
| Regulation of lymph-angiogenesis | GO:1901491 | VASH1 |
| Response to wounding | GO:0009611 | VASH1 |
| (c) North-African populations | ||
| 1. Dandarawi and Fayoumi | ||
| Chloride channel activities | GO:0005254 | CLCC1 |
| Chloride transmembrane transport | GO:1902476 | CLCC1, SLC12A3, SLC12A4, GLRA2 |
| 2. Baladi and Fayoumi | ||
| Dopamine uptake involved in synaptic transmission. | GO:0051583 | SLC6A2, PARK7 |
| Norepinephrine (NE) transport | GO:0015874 | SLC6A2 |
| Oxidoreductase activity | GO:0016491 | HSD11B2 |
| 3. Fayoumi | ||
| 11-B hydroxysteroid dehydrogenase [NAD(P+)] activity | GO:0003845 | HSD11B2, HSD11B1a |
| Anion transmembrane transport | GO:0098656 | SLC12A3, SLC12A4, CLCC1, GLRA2, SLC38A7 |
| Anion transport | GO:0006820 | SLC12A3, SLC12A4, SLC25A24, CLCC1, GLRA2, SLC10A2, SLC38A7, SERINC1, SLC38A8 |
| Bone trabecula formation | GO:0060346 | MMP2, SFRP1, FBN2 |
| Glucocorticoid biosynthetic | GO:0006704 | HSD11B2 |
| Growth factor activity | GO:0008083 | OSGIN1 |
| Regulation of apoptotic process | GO:0043065 | OSGIN1 |
| Regulation of bone remodeling | GO:0046850 | MC4R, TNFRSF11B |
| Response to glucocorticoid | GO:0051384 | HSD11B2 |
| Skeletal system development | GO:0001501 | TRAPPC2, EXT1, DLX6, TRPS1, TNFRSF11B |
| 4. Dandarawi | ||
| Melatonin receptor activity | GO:0008502 | Mel1c (GPR50), MTNR1A, MTNR1B, MTNR1C |
| Response to radiation | GO:0009314 | SFRP2, THBD, CASP3, NPHP1, SDF4, NPHP4, ATM, ERCC5 |
| 5. Baladi | ||
| Protein homotrimerization | GO:0070207 | HSF1, HSF2, HSF3, HSF4 |
1The subset of GO that affect adaptation profile to cellular or environmental stressors and showed to be statistically significant.