Fig. 8.

Parkin-mediated control of DJ-1 is XBP-1 dependent. (A,B) MEF cells invalidated (PK^−/−) or not (PK^+/+) for the parkin gene were treated with vehicle (−) or with the IRE-1 inhibitor 4μ8C (+), in basal (A) and thapsigargin (B) conditions as described in Materials and Methods. Bars correspond to western blot analysis and quantification is expressed as a percentage of the DJ-1 expression in untreated wild-type fibroblasts. Values are the means ± s.e.m. of 12–15 replicates. ***P<0.001; ns, not statistically significant.