Table 1.
Study | Study Design | Study Population | Methods | Significant Findings |
---|---|---|---|---|
Osborne C.A. et al., 2000 [6] | Case-Control Study | 23 asymptomatic asthmatics, 17 healthy subjects | Measured various stable state parameters | PaCO2 and PETCO2 lower in asymptomatic asthmatics |
Van den Elshout et al., 1991 [7] | Case- Control Study | 30 asthmatics, 17 healthy subjects | Induction of hypercapnia and hypocapnia | Hypocapnia induced increases in airway resistance in asthmatic patients |
Raimondi et al., 2013 [8] | Case series | 314 patients admitted for ASA | ABGs, electrolytes and spirometry results documented | Hypocapnia was prominent in less severe asthma exacerbations |
Abbreviations used: ASA = acute severe asthma, ABGs = arterial blood gases, PETCO2 = end-tidal carbon dioxide.