Table 1.
Baseline patient characteristics.
| Variable | Total | No_Downgrade | Downgrade | P value | |||
|---|---|---|---|---|---|---|---|
| N = 860 | N = 528 (61.4%) | N = 332 (38.6%) | |||||
| Median | IQR | Median | IQR | Median | IQR | ||
| Age, year | 67 | 62–71 | 67 | 62–71 | 66 | 62–70 | 0.578 |
| BMI, kg/m2 | 24.09 | 22.38–25.97 | 24.05 | 22.32–25.90 | 24.22 | 22.50–26.00 | 0.608 |
| PSA level, ng/mL | 10.59 | 6.58–19.39 | 12.03 | 7.09–22.72 | 8.60 | 5.99–14.74 | <0.001 |
| PSA group, ng/mL | N | % | N | % | N | % | <0.001 |
| <10 | 445 | 51.7 | 236 | 44.7 | 209 | 63.0 | |
| ≥10 | 415 | 48.3 | 292 | 55.3 | 123 | 37.0 | |
| PSA density, ng/mL2 | 0.33 | 0.20–0.62 | 0.38 | 0.22–0.75 | 0.28 | 0.18–0.50 | <0.001 |
| Prostate volume, mL | 32.0 | 26.0–40.5 | 32.6 | 26.0–40.9 | 31.1 | 25.8–40.0 | 0.367 |
| Clinical stage according to MRI | N | % | N | % | N | % | <0.001 |
| cT2 | 402 | 46.7 | 213 | 40.3 | 35 | 56.9 | |
| cT3a | 292 | 34.0 | 176 | 33.3 | 116 | 34.9 | |
| ≥cT3b | 166 | 19.3 | 139 | 26.3 | 27 | 8.1 | |
| Gleason score according to Biopsy | N | % | N | % | N | % | <0.001 |
| 8 | 623 | 72.4 | 339 | 64.2 | 284 | 85.5 | |
| ≥9 | 237 | 27.6 | 189 | 35.8 | 48 | 14.5 | |
| FU duration after RP, months | 51 | 26–78 | 44 | 25–71 | 59 | 32–83 | 0.317 |
| Pathologic Features after Radical Prostatectomy | |||||||
|
Gleason Score according
to Radical Prostatectomy |
N | % | N | % | N | % | |
| 6 | 19 | 2.2 | - | 19 | 5.7 | ||
| 7 (3 + 4) | 130 | 15.1 | - | 130 | 39.2 | ||
| 7 (4 + 3) | 183 | 21.2 | - | 183 | 55.1 | ||
| 8 | 219 | 25.5 | 219 | 41.5 | - | ||
| ≥9 | 309 | 35.9 | 309 | 58.6 | - | ||
|
Pathologic T Stage according
to Radical Prostatectomy |
N | % | N | % | N | % | <0.001 |
| T2 | 260 | 30.2 | 118 | 22.3 | 142 | 42.8 | |
| T3a | 348 | 40.5 | 208 | 39.4 | 140 | 42.2 | |
| ≥T3b | 252 | 29.3 | 202 | 38.3 | 50 | 15.1 | |
| ECE | 570 | 66.7 | 394 | 74.6 | 180 | 54.2 | <0.001 |
| SVI | 214 | 24.9 | 164 | 31.1 | 50 | 15.1 | <0.001 |
| PSM | 452 | 52.6 | 300 | 56.8 | 152 | 45.8 | 0.002 |
| LVI | 11 | 12.7 | 84 | 15.9 | 25 | 7.5 | <0.001 |
| PNI | 629 | 73.1 | 405 | 76.7 | 224 | 67.5 | 0.003 |
| HGPIN | 371 | 43.1 | 204 | 38.6 | 167 | 50.3 | 0.001 |
| BCR | 502 | 58.4 | 360 | 68.2 | 142 | 42.8 | <0.001 |
IQR, interquartile range; BMI, body mass index; PSA, prostate-specific antigen; MRI, magnetic resonance imaging; RP, radical prostatectomy; ECE, extracapsular extension; SVI, seminal vesicle invasion; PSM, positive surgical margin; LVI, lymphovascular invasion; PNI, perineural invasion; HGPIN, high-grade prostatic intraepithelial neoplasia; BCR, biochemical recurrence.