Table 2.
Genes exhibiting different somatic mutation rates in African American (AA) and Caucasian American (CA) patients with multiple myeloma.
| Gene symbol | Gene name | Mutated in AA (%) | Mutated in CA (%) | AA vs CA ratio | p value |
|---|---|---|---|---|---|
| ABI3BP | ABI family member 3 binding protein | 3.9 | 1.0 | 3.9 | 0.015 |
| ANKRD26 | Ankyrin repeat domain 26 | 3.1 | 0.2 | 16 | <10-3 |
| AUTS2 | Activator of transcription and developmental regulator | 3.9 | 1.2 | 3.3 | 0.028 |
| BCL7A | BCL tumor suppressor 7A | 3.9 | 0.8 | 4.9 | 0.007 |
| BRWD3 | Bromodomain and WD repeat domain containing 3 | 3.9 | 0.8 | 4.9 | 0.007 |
| DDX17 | DAED-box helicase 17 | 3.1 | 0.7 | 4.4 | 0.016 |
| GRM7 | Glutamate metabotropic receptor 7 | 3.9 | 1.0 | 3.9 | 0.015 |
| IRF4 | Interferon regulatory factor 4 | ND | 3.2 | N/A | 0.041 |
| MYH13 | Myosin heavy chain 13 | 3.9 | 0.8 | 4.9 | 0.007 |
| PARP4 | Poly(ADP-ribose) polymerase family member 4 | 3.9 | 1.0 | 3.9 | 0.015 |
| PLD1 | Phospholipase D1 | 3.1 | 0.3 | 10 | 0.002 |
| PTCHD3 | Patched domain containing 3 | 4.7 | 1.0 | 4.7 | 0.003 |
| RPL10 | Ribosomal protein 10 | 4.7 | 1.0 | 4.7 | 0.003 |
| RYR1 | Ryanodine receptor 1 | 9.4 | 4.9 | 1.9 | 0.045 |
| SPEF2 | Sperm flagellar 2 | 3.9 | 0.8 | 4.9 | 0.001 |
| STXBP4 | Syntaxin binding protein 4 | 3.1 | ND | N/A | <10-3 |
| TP53 | Tumor protein p53 | 1.6 | 6.3 | 0.25 | 0.035 |