Figure 2.

The role of mitochondria for induction of pyroptosis. Drug-treated cells receive signals through cell membrane receptors, and the drug invades the cytoplasm. The drugs altered the significant functions of mitochondria lead to the release of reactive oxygen species (ROS) and cardiolipin, which are actively involved in NLRP inflammasome formation and Caspase-1 activation. Activated Caspase-1 produces cleaved gasdermin to initiate pyroptosis-mediated cell death by cell membrane swelling, pore formation, and eventual lysis.