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Molecular mechanism of inflammasome activation for pyroptosis. The inflammasome sensors present on the cell membrane detect drug molecules and activate Caspase-1 through the ASC or NLR adaptor. Active Caspase-1 cleaves the gasdermin family and binds to the plasma membrane, generating cell blebbing and membrane rupture and ultimately promoting pyroptosis. These pores can also facilitate the extracellular release of mature IL-1β and IL-18 to induce pyroptosis in cancer cells.
