Table 3.
Diagnostic performances of IgG index, IgG loc, K index and K loc for MS diagnosis.
| MS Diagnosis | ||||
|---|---|---|---|---|
| IgG Index | IgG loc | K Index | KFLC loc | |
| Sensitivity (%) | 49.6 (42.5–56.7) | 51.3 (42.4–60.1) | 96.1 (90.8–98.5) | 95.8 (90.5–98.2) |
| Specificity (%) | 88.5 (84.2–92.7) | 90.7 (86.6–93.7) | 77.9 (72.0–83.7) | 80.7 (75.5–85.0) |
| Likelihood ratio for a positive test | 4.3 (3.1–7.0) | 5.5 (3.6–8.4) | 4.4 (3.1–5.9) | 5.0 (3.9–6.4) |
| Likelihood ratio for a negative test | 0.6 (0.5–0.7) | 0.5 (0.4–0.7) | 0.05 (0.02–0.11) | 0.05 (0.02–0.12) |
| Positive predictive value (%) | 67.7 (58.2–76.9) | 71.8 (61.4–80.2) | 68.2 (60.9–75.4) | 69.5 (62.1–76.0) |
| Negative predictive value (%) | 78.4 (73.3–82.9) | 80.2 (75.3–84.4) | 97.6 (94.5–98.8) | 97.6 (94.6–98.9) |
| Efficiency (%) | 75.8 (70.1–80.7) | 78.3 (73.9–82.2) | 83.9 (80.7–87.5) | 85.4 (81.5–88.6) |
| Pre-test probability (prevalence) (%) | 32.6 (28.0–37.2) | 31.5 (27.0–36.3) | 33.0 (28.5–38.3) | 31.5 (27.0–36.3) |
| Pre-test odds | 0.5 (0.4–0.6) | 0.5 (0.4–0.6) | 0.5 (0.4–0.6) | 0.5 (0.4–0.6) |
| Post-test odds | 2.1 (1.2–3.4) | 2.5 (1.4–4.8) | 2.1 (1.5–3.7) | 2.1 (1.5–3.6) |
| Post-test probability (%) | 67.7 (57.9–76.8) | 71.8 (57.4–82.8) | 68.2 (58.0–67.3) | 69.5 (58.8–78.5) |
| Number needed to diagnose (NND) | 2.6 (3.8–2.1) | 2.4 (3.5–1.9) | 1.5 (1.5–1.2) | 1.5 (1.5–1.2) |
The analysis was performed for MS patients versus non-MS patients; data are reported with their 95% confidence intervals.