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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Org Biomol Chem. 2017 Aug 16;15(32):6792–6799. doi: 10.1039/c7ob01533j

Fig. 5.

Fig. 5

Antithrombin stabilization assay with substrates modified by sHS. UFH (unfractionated heparin) and pentasaccharide (Arixtra™) were used as positive control, since they are already described as anticoagulant drugs. AT was incubated with different substrates and subjected to a step-wise temperature gradient. The melting temperatures for each condition are shown. Only the UFH and the pentasaccharide were able to stabilize AT, whereas none of the compounds (HepNSulfo[35]S-sulfate and HepNAc[35]S-sulfate) modified by the sHS and their counterpart (HepNSulfo and HepNAc) did.