Table 1.
General characteristics of children with invasive pneumococcal disease before and after PCV introduction
| 2006–2008 | 2009–2011 | |
|---|---|---|
| n = 101 | n = 58 | |
| Age, mean (IQR) | 1.17 (0.75–2.88) | 2.5 (1.17–7.08) |
| <2 years, n (%) | 69 (68.3) | 24 (41.4)* |
| 2–6 years, n (%) | 19 (18.8) | 14 (24.1) |
| 6–18 years, n (%) | 13 (12.9) | 20 (34.5)* |
| Male sex, n (%) | 59 (48.4) | 30 (51.7) |
| Source of S. pneumoniae culture, n (%) | ||
| Blood | 59 (58.4) | 37 (63.8) |
| Cerebrospinal fluid | 29 (38.7) | 11 (19.0) |
| Pleural fluid | 7 (6.9) | 5 (8.6) |
| Other | 6 (5.9) | 5 (8.6) |
| IPD medical condition, n (%) | ||
| Pneumonia | 48 (47.5) | 30 (51.7) |
| Meningoencephalitis | 39 (38.6) | 13 (22.4)** |
| Sepsis-bacteremia | 8 (7.9) | 8 (13.8) |
| Other | 3 (3.0) | 7 (12.1) |
| Fatal cases, n/N (%) | 20/91 (22.0) | 4/53 (7.0)** |
| Pneumonia | 7/43 (16.3) | 0/29 (0.0)** |
| Meningitis | 11/34 (32.3) | 2/11 (18.2) |
| Other | 2/8 (25) | 2/13 (15.4) |
IQR, interquartile range.
*P < 0.001, ** P < 0.05.