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. 2019 May 14;17:155. doi: 10.1186/s12967-019-1912-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Structure of the pipeline and different steps are shown. This consist of the data quality checks (Purple), feature selection with optimised parameters (Green), identification of the biomarkers (Green), and finally accessing the clinical relevance of the markers based on the stability analysis and data visualization (Brown)