Table 3.
Univariate and multivariate logistic regression predictors of hilar lymph node metastasis
| Independents Variables | Univariate Predictors | Multivariate Predictors | ||
|---|---|---|---|---|
| N Metastasis/N total | Odds Ratio (95% CI), P-value | B | Odds Ratio (95% CI), P-value | |
| Age (years) | ||||
| ≤ 60 | 31/243 (12.8%) | Reference | ||
| > 60 | 33/245 (13.5%) | 1.07 (0.63–1.80), 0.816 | ||
| Sex | ||||
| Female | 23/238 (9.7%) | Reference | ||
| Male | 41/250 (16.4%) | 1.83 (1.06–3.16), 0.029* | ||
| Maximum diameter of tumor | ||||
| ≤1.6 cm | 10/228 (4.4%) | Reference | ||
| > 1.6 cm | 51/256 (19.9%) | 5.42 (2.68–10.97), < 0.0001* | ||
| Position | 0.122* | |||
| Right Upper Lobe | 15/157 (9.6%) | Reference | ||
| Right Middle Lobe | 5/20 (25.0%) | 3.16 (1.01–9.90), 0.049* | ||
| Right Lower Lobe | 13/68 (19.1%) | 2.24 (1.00–5.01), 0.050* | ||
| Left Upper Lobe | 16/110 (14.5%) | 1.61 (0.76–3.42), 0.213 | ||
| Left Lower Lobe | 6/80 (7.5%) | 0.77 (0.29–2.06), 0.600 | ||
| Ipsilateral Mixed lobes | 7/33 (21.2%) | 2.55 (0.95–6.86), 0.064* | ||
| Bilateral Mixed lobes | 2/16 (12.5%) | 1.35 (0.28–6.53), 0.707 | ||
| Pathological type | ||||
| Adenocarcinoma | 51/370 (13.8%) | Reference | ||
| Others | 13/118 (11.0%) | 0.77 (0.41–1.48), 0.439 | ||
| Tumor differentiation | ||||
| No | 3/101 (3.0%) | Reference | ||
| Yes | 60/368 (16.3%) | 6.36 (1.95–20.74), 0.002* | ||
| Pathological morphology | ||||
| No | 21/167 (12.6%) | Reference | ||
| Yes | 42/306 (13.7%) | 1.11 (0.63–1.94), 0.725 | ||
| Pulmonary membrane invasion | ||||
| No | 33/342 (9.6%) | Reference | ||
| Yes | 14/55 (25.5%) | 3.20 (1.58–6.47), 0.001* | ||
| Bronchial mucosa and cartilage invasion | ||||
| No | 44/436 (10.1%) | Reference | ||
| Yes | 20/52 (38.5%) | 5.57 (2.94–10.56), < 0.0001* | 1.13 | 3.11 (1.19–8.13), 0.021# |
| Vascular invasion | ||||
| No | 45/445 (10.1%) | Reference | ||
| Yes | 19/41 (46.3%) | 7.68 (3.86–15.26), < 0.0001* | 1.09 | 2.98 (1.14–7.81), 0.026# |
| Nerve invasion | ||||
| No | 59/477 (12.4%) | Reference | ||
| Yes | 5/11 (45.5%) | 5.90 (1.75–19.95), 0.004* | ||
| CEA | ||||
| ≤2.21 ng/ml | 5/197 (2.5%) | Reference | ||
| > 2.21 ng/ml | 44/219 (20.1%) | 9.66 (3.74–24.90), < 0.0001* | 2.14 | 8.49 (2.49–28.97), 0.001# |
| Albumin | ||||
| ≤43.1 g/l | 45/247 (18.2%) | Reference | ||
| > 43.1 g/l | 16/227 (7.0%) | 0.27 (0.11–0.64), 0.003* | ||
*Only variables with P value less than 0.20 were included in the multivariate analysis. # P < 0.05 Sum might not always be in total because of missing data