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. 2019 May 8;9:357. doi: 10.3389/fonc.2019.00357

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Copyright © 2019 Fan, Zhao, Wang, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mutations of PTEN are not associated with ccRCC prognosis and drug selection. (A) Correlation between the PTEN mutation and mRNA expression. (B,C) Kaplan–Meier survival and disease recurrence curves for renal clear cell carcinoma patients stratified by the PTEN mutation. (D,E) Scattered plot and volcano plot show that multiple cancer cell types with the PTEN mutation were significantly inhibited by GSK690693. (F) Reproduction of the GDSC database by excluding cancer of other types showed that RCC cells with the PTEN mutation was also significantly inhibited by GSK690693. *P < 0.05, ***P < 0.001.