Table 5.
Non-susceptibility rates of S. aureus in pediatric population in China [N (%)]
| No. of isolates | PEN | OXA | ERY | CLI | TET | GEN | CHL | RIF | CIP | SXT | MDR | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MRSA | 211 | 207 (98.10) | 176 (83.41) | 208 (98.58) | 181 (85.78) | 103 (48.82) | 38 (18.01) | 121 (57.35) | 22 (10.43) | 65 (30.81) | 5 (2.37) | 169 (80.09) |
| Dysfunctional agr | 8 | 8 (100.0) | 7 (87.50) | 8 (100.0) | 7 (87.50) | 6 (75.00) | 6 (75.00) | 3 (37.50) | 1 (12.50) | 7 (87.50) | 3 (37.50) | 7 (87.50) |
| Functional agr | 203 | 199 (98.03) | 169 (83.25) | 200 (98.52) | 174 (85.71) | 97 (47.78) | 32 (15.76) | 118 (58.13) | 21 (10.34) | 58 (28.57) | 2 (0.99) | 162 (79.80) |
| aP-value | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 0.1627 | 0.0005 | 0.2904 | 0.5921 | 0.0013 | 0.0003 | 1.0000 | |
| MSSA | 58 | 54 (93.10) | 0 | 58 (100.00 | 19 (32.76) | 11 (18.97) | 12 (20.69) | 33 (56.90) | 0 | 11 (18.97) | 0 | 43 (74.14) |
| Total | 269 | 261 (97.03) | 176 (65.43) | 266 (98.89) | 200 (74.35) | 114 (42.38) | 50 (18.59) | 154 (57.25) | 22 (8.18) | 76 (28.25) | 5 (1.86) | 212 (78.81) |
| bP-value | 0.0688 | < 0.0001 | 1.0000 | < 0.0001 | < 0.0001 | 0.7033 | 1.0000 | 0.0057 | 0.0990 | 0.5883 | 0.3648 |
All isolates were susceptible to vancomycin and linezolid, and hence, not listed in the table
PEN Penicillin, OXA oxacillin, ERY Erythromycin, CLI Clindamycin, TET Tetracycline, GEN Gentamicin, CHL Chloramphenicol, CIP Ciprofloxacin, RIF Rifampin, SXT Trimethoprim-sulfamethoxazole
MDR multi-drug resistance, MDR-MRSA resistant to ≥3 classes of non-β-lactam antimicrobials, MDR-MSSA resistant to ≥3 classes of antibiotics including β-lactam antibiotics
aComparison between agr dysfunctional and agr functional isolates among MRSA
bComparison between MRSA and MSSA isolates